Research
We decipher genetic circuits pivotal in determining viral fates. Our mission not only pivots on understanding the architecture of the fate-dictating genetic circuits, but leverages these design principles to engineer indomitable therapies — therapies envisioned to outsmart viral evolution with a towering genetic barrier. With a particular intrigue in the shadowy realm of latency, oncogenesis, developmental disorders associated with DNA viruses, the transmission mechanics of pandemic potential RNA viruses, we dive deep, exploring, understanding, and innovating to make the next-generation medicine and help human health.
Publications:
2. Chaturvedi et al. (2022). A single-administration therapeutic interfering particle reduces SARS-CoV-2 viral shedding and pathogenesis in hamsters. PNAS. PMID: 36074824
3. Chaturvedi* et al. (2021). Identification of a Therapeutic Interfering Particle — a single-administration SARS-CoV-2 antiviral with a high barrier to the evolution of resistance. Cell. PMID: 34838159. *co-corresponding authors
Research Highlight: Villanueva MT (2021). Interfering viral-like particle inhibit SARS-CoV-2 replication. Nature Reviews Drug Discovery. PMID: 34873320
4. Desai RV, Chen X, Martin B, Chaturvedi S et al. (2021). A DNA repair pathway can regulate transcriptional noise to promote cell fate transitions. Science. PMID: 34301855
5. Chaturvedi et al. (2020). A molecular mechanism for probabilistic bet hedging and its role in viral latency. PNAS. PMID: 32632017
6. Chaturvedi et al. (2020). The HSV-1 ICP4 transcriptional auto-repression circuit functions as a transcriptional “accelerator” circuit. Frontiers in Cellular and Infection Microbiology. PMID: 32670890
7. Chaturvedi et al. (2019). Studying RNA-Protein Interaction using Riboproteomics. Methods in Molecular Biology: RNA Analysis. PMID: 32797461
8. Vardi N, Chaturvedi et al. (2018). Feedback-mediated signal conversion promotes viral fitness. PNAS. PMID: 301504129. Chaturvedi et al. (2018). Molecular and biological factors regulating the genome packaging in single-strand positive- sense tripartite RNA plant viruses. Current Opinion in Virology. PMID: 30165268
10. Chaturvedi et al. (2017). Riboproteomics: A versatile approach for the identification of host protein interaction network in noncoding RNAs. PLoS One. PMID: 2907327611
11. Chaturvedi et al. (2016). Functionality of host proteins in Cucumber mosaic virus replication: GAPDH is obligatory to promote interaction between replication-associated proteins. Virology. PMID: 27077230
12. Chaturvedi et al. (2016). A shift in plant proteome profile for Bromodomain containing RNA binding Protein (BRP1) in plants infected with Cucumber mosaic virus and its satellite RNA. Journal of Proteomics. PMID: 26463137
13. Chaturvedi et al. (2014). Live cell imaging of interactions between replicase and capsid protein of Brome Mosaic Virus using bimolecular fluorescence complementation: Implications for replication and genome packaging. Virology. PMID: 25046269
14. Rao ALN, Chaturvedi S and Garmann R (2014). Integration of replication and assembly of infectious virions in plant RNA viruses. Current opinion in Virology. PMID: 25308094
15. Kwon SJ*, Chaturvedi S* and Rao ALN (2014). Repair of the 3' proximal and internal deletions of a satellite RNA associated with Cucumber mosaic virus is directed toward restoring structural integrity. Virology. PMID: 24503085
* Sun-Jung Kwon and Chaturvedi S contributed equally to the work.
16. Chaturvedi et al. (2014). A bromodomain containing host protein mediates the nuclear import of a satellite RNA of cucumber mosaic virus. Journal of Virology. PMID: 24284314
Selected by the editors of the Journal of Virology for inclusion in "Spotlight"- a feature in the journal that highlights research articles of significant interest from the current issue.
17. Bamunusinghe, D, Chaturvedi S, Seo JK and Rao ALN (2013). Mutations in the capsid protein of brome mosaic virus affecting encapsidation eliminate vesicle induction in planta: implications for virus cell-to-cell spread. Journal of Virology. PMID: 23741003
18. Seo JK, Kwon SJ, Chaturvedi S and Rao ALN (2013). Functional significance of a hepta nucleotide motif present at the junction of cucumber mosaic virus satellite RNA multimers in helper-virus- dependent replication. Virology. PMID: 23146208
19. Chaturvedi et al. (2012). A simple and robust in vivo and in vitro approach for studying assembly in RNA viruses. Journal of Visualization Experiment. PMID: 22410612
20. de Wispelaere, M, Chaturvedi S, Wilkens S and Rao ALN (2011). Packaging and structural phenotype of brome mosaic virus capsid protein with altered N terminal ß-hexamer structure. Virology. PMID: 21864876
Featured on cover page of the journal (Volume 419, Issue 1).